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Allantoin has been reported to reduces granulosa cells apoptosis in cyclophosphamide (CTX)-injured rats by downregulating the Bax/Bcl-2 ratio (Wang et al., 2023c)

Induction by immunization with purified uveal and skin melanins

As a result, taking into account the relative innocuity of caffeine, the urinary metabolites/caffeine can be used in pharmacogenetics for the determination of the CYP1A2 phenotype (molar ratio of 7-demethylated compoundsAFMU, 1-methylxanthine, 1-methyluric acid, and the immediate precursor paraxanthine), as for the quantitative evaluation of the catalytic activity of XO (molar ratio of 1-methyluric acid to total 1-methyluric acid + 1-methylxanthine [20,21,22,23,24]