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Patients should seek emergency medical help (call 999) if they experience: Difficulty breathing, wheezing, or throat tightness Swelling of the face, lips, tongue, or throat (angioedema) Widespread urticarial rash (hives) developing rapidly Dizziness, fainting, or rapid heartbeat suggesting anaphylaxis These symptoms typically occur within minutes to hours of administration, most commonly with injectable preparations

MitoSOX measurement using MitoSOX Red Mitochondrial Superoxide Indicator (M36008, ThermoFisher Scientific)

Brightens dull, uneven skin tone

It has been shown that lower doses of colchicine are as effective as high doses for an attack of gout, and much better tolerated

& Adams, M

We state plainly where human RCT data is absent