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doi:10.1074/jbc.R800046200 Burczynski ME, Sridhar GR, Palackal NT, Penning TM (2001) The reactive oxygen speciesand Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha, beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene
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The role of gut microbiota in obesity, diabetes mellitus, and effect of metformin: new insights into old diseases
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It also reduces hepatic fat accumulation, which independently worsens insulin sensitivity a relevant secondary benefit given that non-alcoholic fatty liver disease is significantly more prevalent in women with PCOS
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