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3.2.3 Viral Vector and Preformed Fibrils Models Creating a model that shows a large overlap with the human phenotype and pathophysiology is the main objective when generating new animal models

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According to the Centers for Disease Control and Prevention (CDC), early signs such as vomiting and fatigue develop within hours, while severe cases progress to jaundice, confusion, and multi-organ failure if untreated

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However, experimental and clinical studies suggest that UA may predispose to AF either indirectly as a correlate of other factors that increase the risk for AF or directly via electrophysiological effects of UA