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This comprehensive search utilized databases such as PubMed, Scopus, and Web of Science, with keywords including ME/CFS, Gut-Brain Axis, Gut Health, Intestinal Dysbiosis, Microbiome Dysbiosis, Pathophysiology, and Therapeutic Approaches. Where possible, insights from clinical trials and observational studies were included to enrich the findings

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Whereas biologics are delivered by subcutaneous or intravenous injection, many small molecule drugs can be administered orally or topically

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Where researchers do add compounds, they are usually pursuing a different axis entirely for example a GH-axis or metabolic peptide for goals KLOW does not target