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10.1016/j.cbpc.2010.10.004 45 LushchakV

The peptide decreases infarct size, preserves cardiac function, and reduces arrhythmias in experimental myocardial infarction models

The mechanism involves shifting melanogenesis from eumelanin (dark pigment) to pheomelanin (lighter pigment) and disrupting the binding between tyrosinase and L-DOPA (Abidin et al., 2025)

The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas

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This may explain why p21 overexpression alone was not sufficient to fully inhibit ferroptosis in our hands: p53 stabilization is needed together with p21 induction for complete inhibition of RNR complex expression and function