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Gene overexpression and knock-down studies have demonstrated a strong association between increased CYP2E1 activity and alcohol-induced fatty liver 35,36

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A cooperative role of NRF2 and C/EBP (a transcription factor of the CCAAT/enhancer binding protein family) was described in generating tumor-specific enhancers that promote tumor initiation via NOTCH3 activation (Okazaki et al, 2020)

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