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Although xCT expression is confined to the plasma membrane in normal tissues (36,39), it is upregulated in certain types of cancer, such as colorectal cancer, malignant glioma and non-small cell lung cancer, which increases cystine uptake (4042)

It is sold in weekly subcutaneous injections at five doses from 2.5 mg through 15 mg, and the Phase 3 SURMOUNT trials showed average weight loss of roughly 20 to 22 percent at the highest dose over 72 weeks

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