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Andrew: That it's also just that the sheer literal weight

We propose a predisposition to tissue fragility in patients with clEDS, in particular of the gastrointestinal tract and emphasize the importance of counseling with regard to the risk of gastrointestinal complications

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Further supporting the above are the findings that low tissue copper, in itself, may increase stem cell proliferation and availability in animals

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Activity modification during the recovery period prevents re-injury while allowing appropriate loading