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Moreover, inflammatory mediators, such as Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and Tumor necrosis factor-alpha (TNF-) increased, while pivotal proteins involved in dendritic and synaptic development, such as Synaptophysin (SYP), postsynaptic density protein 95 (PSD95) and brain-derived neurotrophic factor (BDNF) decreased in APP/PS1 mice

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False discovery rate (FDR) control was applied using the BenjaminiHochberg method at a threshold of 0.1

For deficiency states, the evidence is strong: vitamin B6, B12, thiamine, niacin, folate, and calcium all have solid evidence for correcting their respective deficiencies