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When tumours reached ~100 mm 3 on average per genotype, animals were randomized by ranked allocation across all groups and given 5FU (10 mg kg 1 ), metformin (250 mg kg 1 ) or vehicle (PBS) daily by i.p

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This is another one of those experiment and track it situations: Keep track of your workouts and note any mast cell-related responses over the following 24 hours