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although its chemical activity is similar to the original drug, MTX-PG 2-6 is preferentially kept in the intracellular environment [whereas non-glutamylated MTX is quickly exported by ABC transporters (8)], and cellular sensitivity to MTX is directly related to the intracellular pool of MTX-PGs (9)

References 1 AaronsonD

Clin Rev Allergy Immunol 61(3):324338

Stretch marks can also result from abnormal formation of collagen in skin, or potentially from medicine or chemicals that interfere with collagen formation

One of the most common mistakes in regenerative medicine is assuming that if a protocol helped someone else, it must be appropriate for everyone

Therefore, potential inhibitors will not cause side effects in patients