However, it is known that through dietary intake and/or supplementation, antioxidants such as vitamin C, E, and carotenoids are deposited into the epidermis at higher concentrations compared with the dermis [4,5,6], which suggests the importance of inside to outside treatment of the skin
Myer found that many of his patients were deficient in nutrients critical for tissue repair, enzyme production, energy, and hormone balance
Any references to overlapping pathway activity are included solely for scientific context and do not imply that the blend is intended to heal, regenerate, or treat any condition
Among the up to 500 genes that SF can upregulate through the Keap1/Nrf2/ARE signaling pathway are the antioxidant and detoxification enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase-1 (HO-1 or HMOX), profiled in the following section, as well as catalase (Cat), superoxide dismutase(s) (SOD), peroxiredoxins (Prx), heat shock proteins (HSP), glutathione S -transferases (GST), thioredoxin reductase (Trx), glutathione synthetase (GS), glutathione peroxidases (GPx) and glutathione reductase in the brain [38,48]
These measures are small but meaningful: they keep recovery simple and predictable
Nakagawa Y., et al
