39 KalsbeekA.PalmI
During 72 weeks of treatment, people taking tirzepatide at doses of 5, 10, or 15 mg lost an average of 15.0%, 19.5%, and 20.9%, respectively, compared with just 3.1% in people taking a placebo
There are also vitamin B12 multivitamins or supplements
They sit near the top of the evidence hierarchy, just below meta-analyses (which combine multiple RCTs)

Advantages over Neurobion oral tablets: 100% bioavailability via injection vs 4060% for oral tablets Faster achievement of therapeutic blood levels Bypasses impaired gut absorption in patients with GI conditions, post-gastric surgery, or malabsorption syndromes The Three Active Vitamins Detailed Breakdown Why Injections Are Superior in Certain Cases 100% bioavailability: Bypasses the digestive system, delivering the full dose directly to the bloodstream Rapid correction of severe deficiency: Therapeutic levels in hours rather than days or weeks For patients with impaired absorption: GI disease, elderly patients, post-gastric surgery, short bowel syndrome In acute neurological pain: High concentrations of B1, B6, and B12 via injection have demonstrated superior efficacy in reducing neuropathic symptoms How Neurobion Ampoules Supports Nerve Health B1 Nerve Fuel: Provides the energy essential for nerve cells via the Krebs cycle

It is not approved by the FDA, EMA, or any regulatory authority for human therapeutic use, diagnosis, treatment, or supplementation