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3 Conclusion Reactive oxygen species (ROS) is an umbrella term that contains oxygen radicals and non-radical compounds such as hydrogen peroxide (H 2 O 2 ), hydroxyl radicals, lipid radicals, and (phosphorus) lipid hydroperoxides ( 2 O 2 and organic hydroperoxides to water and corresponding alcohols, respectively

301 The potential mechanisms related to gut microbiome activities and IR are very complex, and numerous studies with contradictory results render it difficult to identify clear mechanistic pathways

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Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis