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[1] Other manifestations of B12 deficiency include glossitis (sore, red tongue), mouth ulcers, visual disturbances, and in severe cases, psychiatric symptoms such as depression, psychosis, or dementia-like presentations

"That is a much bigger effect than what we would initially anticipate." The research finds that during stress, the sympathetic nervous system over-activates and so depletes the stem cells that make pigment cells

A potential concern with dietary supplements is the lack of regulatory oversight

Locigno R, Pincemail J, Henno A, et al

There were higher levels in the high-dose group (3035% increase vs 17% increase in the low-dose group)