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Nature 540 , 552558 (2016)

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Concentration-wise, this ingredient is rarely used pure and usually shows up as part of a standardized centella extract where reported content ranges from 0.02-3.06%

For example, Lactiplantibacillus plantarum precolonization led to the upregulation of 12-oxo phytodienoic acid and downregulation of antioxidants and lipid peroxidation products, indicating reduced oxidative stress and a shift in host metabolic state that may underlie its protective effects against caries (Wu et al., 2025)

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