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Unfortunately, as further results of studies indicate, increased activity of antioxidant enzymes was not enough to counterbalance ROS, since significantly higher concentrations of thiobarbituric reactive substances (TBARS, products of lipid peroxidation) and carbonyl groups (products of protein oxidation) were observed vs

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In some embodiments, the steady state concentration of an active agent released from a controlled-release otic formulation described herein is from about 20 to about 50 times the steady state concentration of an active agent released from a formulation that is not a controlled-release otic formulation

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