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Abnormal activation of tryptophan-kynurenine pathway in women with polycystic ovary syndrome

In addition to the intratubular crystal deposition and nidus formation, mitochondrial dysfunction is also associated with Randalls plaque formation by enhancing tissue inflammation and interstitial deposition of calcium phosphate (hydroxyapatite)

Provider guidance on injection technique, storage, and adherence is essential for optimizing outcomes