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Polyunsaturated fatty acids (PUFAs), which serve as the main substrates for lipid peroxidation, require esterification and incorporation into membrane phospholipidsespecially polyunsaturated fatty acid-phosphatidylethanolamine (PUFA-PE)to participate in ferroptosis signaling processes ( Fe 2+ within cells generates hydroxyl radicals (OH) through the Fenton reaction, thereby initiating the peroxidation of PUFAs ( - -GSH-GPX4 axis
In-frame exon skipping may generate a partially functional protein in recessive disease
This study enrolled 2967 patients who were treated with levocarnitine for at least 3 months and had a 3-month or longer pre-levocarnitine period
Endocrinology 148 , 39873997 (2007)
Int Immunopharmacol (2018) 56:6570
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