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on 38 observational cohort and casecontrol studies, only 29.1% of melanomas likely arose from a preexisting nevus and 70.9% arose de novo (54)
Lipids, especially polyunsaturated fatty acids (PUFAs) in membrane phospholipids, are prime targets for ROS-induced peroxidation ( ROS also damage nucleic acids, particularly guanine bases, resulting in eight-oxoguanine formation, DNA strand breaks, and telomere shortening (Zhou et al., 2025)
Concerning MDA, a significant elevation of prefrontal cortical MDA level was observed in Doxorubicin and Cyclophosphamide-treated group relative to the control group by 1.43 folds
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