Clinical candidates modulating protein-protein interactions: The fragment-based experience
Upon glutamine starvation, p53 activity is induced and can help cancer cells adapt to nutrient starvation through diverse mechanisms 148
Canonical Wnt/-catenin signaling pathway is activated via increased production of Wnt ligands by NTAPP To investigate whether NTAPP exposure affect a biological response via the canonical Wnt/-catenin signaling pathway, we treated hDP cells with two types of pharmacological inhibitor of Wnt/-catenin signaling, endo-IWR1 25 and IWP2 26 before NTAPP treatment
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Hum Mol Genet 8 : 425430 Campo GM, D'Ascola A, Avenoso A, Campo S, Ferlazzo AM, Micali C, Zanghi L, Calatroni A 2004 Glycosaminoglycans reduce oxidative damage induced by copper (Cu +2 ), iron (Fe +2 ) and hydrogen peroxide (H2O2) in human fibroblast cultures