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One of the limitations of this study is its exclusive focus on the mesolimbic DA pathway in alcohol nave rats, which is only representative of the initial phase of AUD

Consistently, the induction of profibrotic genes ( Col1a1, Col3a1, Fn1, Eln, Ccn2, and Acta2 ) and kidney injury markers ( Ngal, Kim-1 ) following UUO was blunted in Usp2 KO mice (Fig

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GSH levels and the GSH/GSSG ratio are important indicators of oxidative stress and redox balance, with decreased GSH levels and increased GSSG levels being associated with neurological aging

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