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In the end, all health-related decisions must be based on evidence rather than trends or quick promises

TCM is associated with Qi stagnation, blood stasis, and phlegm accumulation

The elevated expression of the substrate adaptor p62 protein inhibits Nrf2 degradation and promotes subsequent Nrf2 nuclear accumulation by inactivating Keap1 (Sun et al., 2016b)

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It therefore suggests that peripheral concerns when inhibiting GSK-3 might be manageable, owing to the additional benefit that FUS-BBB opening in promoting localized CNS GSK-3 inhibitor deposition and hence reduce systemic retention

14 , e1002516 (2016)