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Thein-Han W, Liu J, Xu HH

This method allows for bypassing first-pass metabolism, ensuring reliable therapeutic concentrations, and providing better dosage bioavailability

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doi: 10.1142/s0192415x22500537 114 TaillibertSLe RhunEChamberlainMC

Conversely, decreased GH/IGF-1 signaling has also been shown to extend longevity in a wide variety of species such as worms, fruit flies, mice, and yeast (468), thus raising the question of whether decreased activity of the GH/IGF-1 axis might be beneficial for human longevity

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