Food and Drug Administration Updated 503A bulk drug substances list (Category 2 revision, effective April 22, 2026)
Studies show 8-mL injections deliver superior outcomes versus 4-mL volumes
Distribution then occurs rapidly throughout the cortex, hypothalamus, and other brain regions
Notably, self-employed people or those who otherwise buy health insurance using Federal or state health care exchanges are required to switch to Medicare at age 65, so this only applies to people working as employees (or to the spouses of employees) of a company that offers employer-sponsored qualifying HDHP insurance
The full list includes: BPC-157 (Body Protection Compound-157) TB-500 (Thymosin Beta-4) MOTS-C (Mitochondrial-derived Peptide) GHK-Cu (Copper-binding Tripeptide) Semax (Synthetic ACTH analog) Selank (Synthetic tuftsin analog) DSIP (Delta Sleep-Inducing Peptide) Epithalon (Epithelial Peptide) Kotan (Derivative of Selank) CG-250 (Radiolabeled somatostatin analog, limited clinical use) N-Acetyl Semax (Semax variant) Dihexa (Angiotensin IV analog, nootropic applications) The announcement did not move these peptides to Category 1 a distinction that matters
Simply hold the reconstituted solution under the tongue for 60 seconds before swallowing
