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developed a lipid nanoparticle delivery system for melphalan and miRNA-181a, resulting in superior transfection efficiency and reduced toxicity in Y79 cells and RB heterotopic transplant rat models [316] ( Fig

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Our computations show that the sexual dimorphism in one-carbon metabolism plays only a small role in the glutathione pathway (the velocity of CBS is not much different in the two cases, Table 1)

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