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Furthermore, increased ACE2 expression in alveolar type II pneumocytes and alveolar macrophages of individuals with severe SARS-CoV-2 disease (ARDS with diffuse alveolar damage) requiring mechanical ventilation (Baker et al., 2021) favors a concomitant increase in oxidative stress in those individuals

Dry N, Pilgrim M, Gibala M, Gillen J, Wojtowicz JM, MacQueen G, et al

Furthermore, the overproduction of ECM proteins and excessive fibrosis can be caused by the activation of a specific subset of fibroblasts called myofibroblasts that can contract wound edges by the contractile protein alpha-smooth muscle actin (-SMA

Gut physiology and environment explain variations in human gut microbiome composition and metabolism

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The imbalance in copper metabolism in DCM presents a paradox