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doi: 10.1196/annals.1320.019 40 PennistonKLTanumihardjoSA

An imbalance between reactive oxygen species (ROS) production and antioxidant defenses leads to oxidative stress (Figure 1), causing disrupted redox signaling or molecular damage [1,2,3]

For a long time, hydrogen peroxide (H 2 O 2 ) was considered as a classic model for oxidative stress, and it can also activate ER stress through modulation of ROS generation ( 2 O 2 has been demonstrated that would increase ROS levels and induce ER stress in a dosage-dependent manner ( 2 O 2

24 The peptides ability to modulate nitric oxide and inflammatory cytokines may underlie these effects

Integrin 51, a receptor for fibronectin, mediates interactions between the cell surface (through actin filaments) and the immediate surrounding matrix, and is involved in the initiation of mechanotransduction in intervertebral disc cells 32