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Although the exact mechanism of RA remains elusive, immune cells and fibroblast-like synoviocytes (FLS) are thought to be involved in its progression (129, 130)

This shortening can also be exacerbated by oxidative stress

Bioavailability following subcutaneous injection is estimated at approximately 80%, substantially higher than oral administration, where peptide degradation in the gastrointestinal tract limits systemic exposure

This shorter reconstituted peptide shelf life is due to its increased susceptibility to the following: Hydrolysis Oxidation Aggregation The reason for this is that moisture has been introduced