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In this answer 3 sections The reason you started with intense every other day B12 shots and transitioned to a monthly schedule is a medical strategy called loading and maintenance. When you were first diagnosed, your bodys B12 stores were dangerously low

It is a huge hurdle we and others in the B12 community are working on to overcome

So once your stores are topped up, a maintenance injection is designed to hold you for two to three months

Treatment plans may evolve over time based on response and goals

From the

Vaessen N, Heutink P, Janssen JA, Witteman JCM, Testers L, Hofman A, Lamberts SWJ, Oostra BA, Pols HAP, Van Duijn CM