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Omics technologiesincluding metabolomics, transcriptomics, and proteomicsshould be integrated to systematically characterize the chemical composition and biological effects of SCF

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Since PRDX2 has been shown to be glutathionylated by GSH at its cysteine residues to protect against its hyperperoxidation 41 , it is possible that elevated GSH levels in T315I-Bcr-Abl cells might prevent PRDX2 monomer formation, therefore abrogating ROS-induced replication stress

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Zhang KY, Wang QL, Yang QX, Wei QY, Man N, Adu-Frimpong M, et al