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The GLP-1 and GIP arms slow gastric emptying and blunt appetite (that is where nausea comes from), while the glucagon arm nudges energy expenditure and hepatic fat handling

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D-Nle-X-Ile-NH-(CH 2 ) 5 -CONH 2 analogs affect HGF/Met stimulated MDCK cell proliferation Met activation initiates multiple cellular responses including increased proliferation and motility, enhanced survival, and differentiation

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These effects are mediated largely through activation of AMPK and suppression of mTOR signaling, with Akt also contributing to improved glucose uptake