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Finally, centrifugation at 100,000 g for 90 min, the supernatant was removed and resuspended in 200 L of PBS to obtain the cell supernatant exosomes precipitation

Reducing the expression of inflammatory mediators, immune regulation, anti-oxidative stress, preventing angiogenesis, inhibiting the proliferation and migration of FLSs, and inhibiting the differentiation of osteoclasts are all important mechanisms of natural medicines in the treatment of RA

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