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Gut microbiota exert broad regulatory effects on host metabolism, producing key metabolites such as SCFAs and tryptophan derivatives that maintain bloodbrain barrier (BBB) integrity, modulate neuroinflammation, and support brain energy metabolism

ROS production, lipid peroxidation, protein oxidation and DNA damage in RA patients are increased, and the activity of antioxidant defense system is decreased, resulting in oxidative stress (193)

PLoS ONE 12:e0187964

doi: 10.1159/000443344

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