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Although the mechanisms behind this phenomenon are unclear, PC3 and RM1 both demonstrate heightened Myc activation which is associated with progression of castration-resistant prostate cancer (CRPC) and emergence of neuroendocrine prostate cancer [62,63,64,65] and this evidence could specific neutrophil regulation by aggressive prostate cancer subtypes [63, 66, 67] that promotes an imbalance of ROS in the surrounding microenvironment

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