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mechanically, reactive oxygen species (ROS) can speed up skeletal muscle fatigue by reducing calcium sensitivity [8] and can decrease maximal calcium-activated force [9]

Semin Oncol 16(1 Suppl 2):30-4, 1989

This reliance on correlative evidence from disease contexts has reduced CHAC enzymes to mere stress markers and overlooked their potential as dynamically regulated metabolic integrators

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Statements Data availability statement The data generated in this study can be found in ProteomeXchange: Ethics statement The animal study was reviewed and approved by Animal handling and experimentation were approved by the Laboratory Animal Care and Use Committee of the Shaanxi University of Chinese Medicine