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About 7585% of primary liver cancer cases are HCC (Siegel and Miller, 2019)

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Low-risk patients exhibited reduced expression of biomarkers associated with resistance to CDK4/6 inhibitors (CCNE1, E2F1, E2F2) and PARP inhibitors (BRCA1/BRCA2) , suggesting an enhanced potential for response to PARP and CDK4/6 inhibitor therapies

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