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Alzheimer's disease was officially listed as the sixthleading cause of death in the United States in 2024 and the fifthleading cause of death among Americans age 65 and older

Yet another strategy is to use a molecular degrader of extracellular proteins, which links a target-binding unit (for instance binding to IgG, as with BHV-1300 [418]) to a motif that binds asialoglycoprotein receptors (ASGPR) to direct its targets to endolysosomal degradation in the liver [419, 420]

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44 (6): 707719.e1

Galvn et al., 2008

Acknowledgements The author is very thankful to the research assistant, Eng