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doi: 10.1371/journal.pgen.1000951 86 WeiheA

Its a water soluble vitamin which means excess is excreted as we pass urine

The p53 tumor suppressor is the guardian of the genome that participates in the control of cell survival and division under various stresses

Impaired insulin-stimulated GLUT4 translocation in these tissues underlies insulin resistance, which is a major risk factor for type 2 diabetes and other metabolic diseases

PLoS One 7 (2), e31951

Hence, changes in intra-portal insulin levels need to be taken into consideration to correctly interpret the alterations in the GH/IGF-I axis in healthy and disease states as this helps the clinician in formulating the decision-making process of when and how to perform appropriate diagnostic work-up and whether to offer treatment to improve any accompanying metabolic consequences