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In the absence of coenzyme B12, tetrahydrofolate cannot be regenerated from its inactive storage form, 5-methyl tetrahydrofolate, resulting in functional folate deficiency

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Lipo-C: A cocktail of supplements that combine to support fat metabolism and reduce appetite, target and reduce fat deposits in specific areas (think abdomen, thighs, and hips), aid in liver detox, and boost energy

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However, no published research specifically evaluates combination protocols

Medically Reviewed on 6/10/2026 Harvard T