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Future research should prioritise long-term outcomes in high-risk groups, comparisons of physiological versus pharmacological dosages in healthy subjects, cost-effectiveness analyses, and adherence monitoring to inform clinical guidelines for the management and prevention of B12 deficiency

Imaging studies, where employed, may show tissue changes during mid-phase

3.2 Oncogenes regulate Gln metabolism Some oncogenes have the ability to impact tumor development by modulating key transporters and enzymes in Gln metabolism ( Table 2 )