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The prolonged inflammatory state in chronic wounds also suppresses the function of key immune cells, including neutrophils and macrophages, by altering their cytokine profiles and impairing their ability to phagocytize and clear bacteria [45]

Effects can be noticed within a few days to weeks, with optimal benefits appearing after 2-4 weeks of consistent use

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In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26

It has been under research for over 50 years, with consistent findings of excellent tolerability in both topical and injectable applications

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