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Some evidence suggests that quinones derived from estradiol and specific glutathione S -conjugates of estradiol are potent inhibitors of human GSTM1-1 and GSTA1-1 (Abel et al., 2004)

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In addition, Ding et al

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We've seen this pattern in our experience with countless research compoundsthe most profound effects often come from supporting the body's own elegant, complex systems rather than trying to crudely override them