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However, its efficacy is limited to patients with at least one nonsense mutation who represent only 15% of cystinosis cases [7] and it requires repeated dosing to maintain therapeutic effects

For a deeper dive into this science, you can read Why Research Peptides Are Typically Lyophilized

The modifications made Dihexa much more bioavailable and durable, allowing it to cross the blood-brain barrier

There are also legal considerations because neither peptide is FDA-approved for human use in this manner

A table of pKa values can be found here