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Discovery of 6-diazo-5-oxo-l-norleucine (DON) prodrugs with enhanced CSF delivery in monkeys: a potential treatment for glioblastoma

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The changes in the rating scale scores indicate the presence of moderate depression and anxiety symptoms consistent with major depression and GAD and the presence of a chronic fatigue syndrome (lasting 23 months), including chronic fatigue, insomnia, autonomic and gastro-intestinal symptoms, and, to a lesser extent, cognitive impairments

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