335,336,337,338 As for non-malignant endothelial cells at regular oxygen concentrations, lactate activates hypoxia-inducible factor 1 (HIF-1) that enhance s basic fibroblast growth factor (bFGF) and vascular endothelial growth factor receptor 2 (VEGFR2) expression, which synergizes with lactate-induced VEGF secretion
[DOI] [PubMed] [Google Scholar] 9.Guengerich F.P
Disruption of cysteine uptake and collapse of intracellular GSH pool induces an inhibition of the detoxifying activity of GPx4 and excessive accumulation of oxidatively damaged lipids at the membrane, although it remains unclear if this solely affects the cell plasma membrane, or the effect also extends to organelle membranes
[Crossref] 42
Increasing evidence highlights ferroptosis as a pivotal contributor to the pathogenesis of NDDs (Table 1), suggesting that therapeutic targeting of ferroptosis may offer a promising strategy for the prevention and treatment of NDDs
Reducing Inflammation Chronic inflammation in the gastrointestinal (GI) tract is a major contributor to conditions like IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), or gut damage from ibuprofen and naproxen use
