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This revealed that GHK-Cu influences 31.2% of all human genes at a threshold of 50% expression change an extraordinarily broad biological effect for a single molecule

doi:10.1007/s00167-021-06458-2 Wiley TJ, Lemme NJ, Marcaccio S, et al

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Meanwhile, in VSMCs, mitochondrial ROS trigger a phenotypic switch from a contractile to a synthetic state, enhancing cell proliferation and migration into plaques