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This section delves into the mechanisms by which gut microbiota perturbations influence host inflammatory responses and immune regulation, contributing to the pathogenesis of hypothyroidism (Figure 3)

Diabetes Technol Ther

The power to detect differences between the study groups is larger than what is projected here as we will measure most of the outcomes more than once and also use these repeated measurements in the same analyses, adjusting for interdependence within a child using mixed effects models, generalised estimating equations or other appropriate methods

These transmembrane proteins interact with their partners on the opposing plasma membrane and provide a mechanical link between epithelial cells while establishing a diffusion barrier [22]

doi: 10.3390/nu11092147, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 75

Table 1 Approximate metabolic rates in the non-anesthetized brain cortex from a multitude of 13 C-NMR studies cited in text