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Purity, dosing, long-term outcomes, and safety are not well established in human trials

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Exercise training: significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise

Am J Chin Med 45(3):557573 Nakatogawa H, Suzuki K, Kamada Y et al (2009) Dynamics and diversity in autophagy mechanisms: lessons from yeast [J]

While the goal of surgery is to repair more than you damage, when the repair isnt working, you end up with the cumulative damage done by multiple procedures